Proteins Identified for Alzheimer's Blood Test; July 08, 2014

A major advance has been created in creating a blood test to predict when at- risk people will establish Alzheimer's disease, in accordance with researchers.

Simon Lovestone, a professor of translational neuroscience on the University of Oxford inside the United Kingdom, and colleagues have identified 10 proteins that can predict with 87% accuracy whether someone with mild cognitive impairment will develop Alzheimer's disease within a year.

The study, which included over 1,000 people, was published inside journal Alzheimer's and Dementia, and will also be used to improve research for new drugs to treat Alzheimer's.

"We wish to be able to identify people to enter many studies earlier than they currently do that is certainly really what we have been aiming at," Lovestone told BBC News.

The researchers took blood samples from 1,148 people, 476 of whom had Alzheimer's, 220 with memory problems, and a control group of 452 without signs of dementia. They determined 16 proteins were associated with brain shrinkage and forgetfulness and 10 of those could predict whether someone would develop Alzheimer's.

The test may eventually be designed for doctors to work with on patients. "Having a protein test is often a major step forwards," Ian Pike, PhD, chief operating officer at Proteome Sciences in Cobham, United Kingdom, told BBC News. "It will take several years and need a lot more patients before we are able to be certain these tests are suitable for routine clinical use; that process may start fairly quickly now."

However, it's unlikely that routine testing would be recommended until effective treatments are available.




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