Memory Decline More Rapid in Women Than Men
by N. Blazek;; 7/21/15

Women with mild cognitive impairment experience memory declines two times as fast as men, as outlined by researchers.

Women's scores about the Alzheimer's Disease Assessment Scale- cognitive sub scale (ADAS-Cog) declined in an average rate of 2.3 points annually (N=141) compared to 1.05 in males (N=257), data in the Alzheimer's Disease Neuroimaging Initiative (ADNI) indicate.

The differences in ADAS-Cog scores between genders was highly significant (P=0.005) after adjustment for age, education, baseline mini mental state examination (MMSE), follow-up serious amounts of ApoE4 status. ApoE4 was connected with faster rates of decline within women and men, the study found. Mean follow-up was four years.

“These results examine the chance of established undiscovered gender-specific genetic or environmental risk factors that influence the interest rate of decline,” study researcher Katherine Amy Lin of Duke University Medical Center in Durham, North Carolina, said for the 2015 Alzheimer's Association International Conference.

In a 2nd study, Katie Schenning, MD, MPH, from your Oregon Health & Science University in Portland and colleagues reported that among older patients, women subjected to general anesthesia during surgery declined on measures of cognition, functional status, and brain volumes at significantly faster rates than men which the real difference was more pronounced for females who underwent multiple procedures.

The retrospective cohort analysis involved data on the Oregon Brain Aging Study along with the Intelligent Systems for Assessing Aging Changes, which included 182 those who underwent a complete of 331 procedures with general anesthesia.

Men experienced cognitive declines after experience general anesthesia weighed against their unexposed counterparts around the MMSE (P=0.009), the Instrumental Activities of Daily Living (P=0.024), plus the Clinical Dementia Rating-sum of boxes (CDR-SM, P=0.027), they found.

However, the declines observed among women were a lot more rapid within the following outcomes: MMSE (P<0.001 in ladies), CDR (P=0.003), CDR-SB (P<0.001), Activities of Daily Living (P<0.001), Delayed Logical Memory (P=0.011) and ventricular volume (P=0.005).

“This is just about the first studies to claim that among older adults, women have a higher risk for postoperative brain dysfunction than men,” Scheming said. “Our research clearly shows a link between surgery, general anesthesia and cognitive decline in older adults.”

She needed more studies to verify the finding, in addition to determine whether certain people will be more vunerable to postoperative cognitive decline, and whether sex or genetic risk factors be the cause because susceptibility.

Alzheimer's disease may disproportionally affect women — almost two -thirds of Americans together with the disease are women. By the era of 65 years, ladies have a one-in-six chance developing Alzheimer's compared to a one-in-11 chance of men.

"There is definitely an urgent need to understand if differences in brain structure, disease progression and biological characteristics give rise to higher prevalence rates and rates of cognitive decline," said Maria Carrillo, PhD, the Chief Scientific Officer in the Alzheimer's Association.




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