Even Mild TBI May Cause Brain Damage
Psychiatry Advisor; July 17, 2014
HealthDay News -- Even mild traumatic brain injury may cause brain damage and affect thinking and memory, according to researchers.
Iain D. Croall, from Newcastle University in the United Kingdom, and colleagues scanned 53 patients, about six days post-injury. One year later, 23 patients were rescanned. Thirty-three matched control subjects were also assessed. Cognitive testing was completed during scanning.
Increased axial diffusivity drove a fractional anisotropy (FA) increase acutely, while decreased radial diffusivity drove a bad regression between FA and Verbal Letter Fluency across widespread white matter regions, the study reported in Neurology. This was particularly observed in the ascending fibers from the corpus callosum.
Astrogliosis and compaction of axonal neurofilament are viewed to cause raised FA, which may also affect cognitive functioning. FA was decreased chronically, suggesting myelin sheath disintegration, but remained negatively regressed with Verbal Letter Fluency inside anterior forceps.
"Acute mild/moderate traumatic brain injury is seen as a increased tissue FA, which represents a specific neurobiological link between cognitive dysfunction and white matter injury after mild/moderate injury," the study wrote.